首页> 外国专利> Fibrin / fibrinogen binding conjugate, kit and method for producing a depot of a pharmaceutically active substance, depot of a pharmaceutically active substance, and method for treating a patient suffering from a pathological condition.

Fibrin / fibrinogen binding conjugate, kit and method for producing a depot of a pharmaceutically active substance, depot of a pharmaceutically active substance, and method for treating a patient suffering from a pathological condition.

机译：血纤蛋白/血纤蛋白原结合缀合物，产生药物活性物质贮库的试剂盒和方法，药物活性物质贮库以及治疗患有病理性疾病的患者的方法。

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摘要

"FIBRINE / FIBRINOGEN CONNECTION CONJUGATE, KIT AND METHOD TO PRODUCE A DEPOSIT OF A PHARMACEUTICALLY ACTIVE SUBSTANCE, DEPOSIT OF A PHARMACEUTICALLY ACTIVE SUBSTANCE, AND A METHOD OF A THERAPEUTIC PATHOTE PATIENT. A fibrin / fibrinogen binding conjugate to form a depot for prolonged release of a pharmaceutically active substance from a fibrin clot. The conjugate comprises a fibrin / fibrinogen binding moiety linked to a pharmaceutically active substance either directly or through an intervening substance capture moiety, such as an antibody. The conjugate may also be a recombinant fusion protein comprising a fibrin / fibrinogen binding moiety such as the C-terminal domain of VEGF-185 fused to a wound healing substance such as leptin.

机译：“纤维/纤维蛋白原连接缀合物，试剂盒和产生药物活性物质沉积物，药物活性物质沉积物的方法以及治疗性患者的方法。一种纤维蛋白/纤维蛋白原结合缀合物，用于形成长效蛋白仓库长效剂缀合物包含直接或通过介入物质捕获部分（例如抗体）与药学活性物质连接的血纤蛋白/纤维蛋白原结合部分，该缀合物还可以是重组融合蛋白，其包含纤维蛋白/纤维蛋白原结合部分，例如与伤口愈合物质例如瘦蛋白融合的VEGF-185的C-末端结构域。

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公开/公告号BR0114110A

专利类型
公开/公告日2004-07-06

原文格式PDF
申请/专利权人 BAXTER AKTIENGESELLSCHAFT;BAXTER INTERNATIONAL INC.;
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申请/专利号BR20010114110
发明设计人 HEINZ REDL;WALTER FURST;RUDOLF KNEIDINGER;SAM L. HELGERSON;DOUGLAS L. LOOKER;ELISABETH M. INMAN;JANE P. RICHARDS;CATALINA WONG;
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申请日2001-09-25
分类号C07K14/00;
国家 BR
入库时间 2022-08-21 23:12:17

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