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Structure solution of il-13, active sites of il-13, bonding Agents for il-13 and Methods for Design of bonding Agents for IL - 13
Structure solution of il-13, active sites of il-13, bonding Agents for il-13 and Methods for Design of bonding Agents for IL - 13
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机译：il-13的结构溶液，il-13的活性位点，il-13的结合剂和IL-13结合剂的设计方法
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摘要
We describe a three-dimensional structure in solution of the Human IL - 13. The three-dimensional structure of il-13 may be useful in the design and selection of bonding Agents for il-13. In some embodiments described a Solution containing il-13 and il-13 includes amino acid residues 1 - 113. Il-13 may not be marked or enriched in 15N enriched in 15N, 13C.Il-13 may include four Alpha helices: alfaa, alphabetical, and alfac Alfad, and two beta Chains, beta1 and beta2.The alfaa can include the amino acid residues of the P6 - Q22 il-13 may include the beta1 M33 - W35 of il-13, Alphab can include the amino acid residues of the I52 M43 - il - 13, alfac can include the amino acid residues of the A59 - F70 il-13The beta2 may include amino acid residues k89 E91 of il-13 and Alfad can include the amino acid residues of the r108 V92 - il - 13.In certain embodiments described an active site of IL - 13, where the active site is characterized by a three-dimensional structure that includes the structural coordinates of the amino acid residues I52, q64 R65 and M66, il-13, + / - an average of Quadratic Deviation S of the main Chain Atoms of the conserved amino acids not more than 1,5 Armstrong.It also describes Methods of using the three-dimensional structure of il-13 to design and select agents Union for il-13. Additionally described bonding Agents for il-13.
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