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Novel human leucine-rich repeat-containing proteins specifically expressed in the nervous system

机译:在神经系统中特异性表达的新型富含人亮氨酸的重复序列蛋白

摘要

The present invention describes two newly discovered Human Leucine Rich Repeat (LRR)-containing proteins, HLRRNS-2 and HLRRNS-3, and their encoding polynucleotides. Also described are expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies associated with the polynucleotides and/or polypeptides of the present invention. In addition, methods involving the new HLRR-containing proteins HLRRNS-2 and HLRRNS-3, or modulators thereof, for treating, diagnosing, preventing, and screening for disorders associated with aberrant cell growth, neurological conditions, and diseases or disorders related to the brain are illustrated.
机译:本发明描述了两个新发现的含有人亮氨酸富集重复序列(LRR)的蛋白质,HLRRNS-2和HLRRNS-3,以及它们的编码多核苷酸。还描述了与本发明的多核苷酸和/或多肽相关的表达载体,宿主细胞,激动剂,拮抗剂,反义分子和抗体。另外,涉及新的含HLRR的蛋白质HLRRNS-2和HLRRNS-3或其调节剂的方法,用于治疗,诊断,预防和筛选与异常细胞生长,神经系统疾病以及与疾病相关的疾病或障碍的疾病。说明了大脑。

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