首页> 外国专利> Method for the porduction of artificial oxygen carriers from covalently cross linking haemoglobin with improved functional properties of haemoglobin by cross- linking in the presence of chemically non- reacting effectors of the oxygen affinity of the haemoglobin

Method for the porduction of artificial oxygen carriers from covalently cross linking haemoglobin with improved functional properties of haemoglobin by cross- linking in the presence of chemically non- reacting effectors of the oxygen affinity of the haemoglobin

机译：通过在血红蛋白氧亲和力的化学非反应性效应子存在下进行交联，从具有改善的血红蛋白功能特性的共价交联血红蛋白中引入人工氧载体的方法

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摘要

The invention relates to a method for the preparation of artificial oxygen carriers from chemically cross-linked hemoglobins with improved functional properties, chemically unreactive effectors of the oxygen affinity being added to the hemoglobin, before the latter is cross-linked and being present during the cross-linking. Pursuant to the invention, this leads to a reversible protection of those conformative regions of the hemoglobin molecules, which control the interactions of the hemoglobins with oxygen. This nonchemical protection causes the oxygen binding properties (especially the affinity and cooperativity) to change in a modified manner during a cross-linking of the hemoglobin's.

机译：本发明涉及一种由化学交联的血红蛋白制备人造氧载体的方法，所述化学交联的血红蛋白具有改善的功能特性，在血红蛋白交联并在交联过程中存在之前，将氧亲和力的化学非反应性效应物加入血红蛋白中。 -链接。根据本发明，这导致血红蛋白分子的那些构象区的可逆保护，其控制血红蛋白与氧气的相互作用。这种非化学保护导致氧结合特性（尤其是亲和力和协同性）在血红蛋白的交联过程中以修饰的方式改变。

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公开/公告号US2004023851A1

专利类型
公开/公告日2004-02-05

原文格式PDF
申请/专利权人 BARNIKOL WOLFGANG;
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申请/专利号US20030312427
发明设计人 WOLFGANG BARNIKOL;
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申请日2003-05-22
分类号A61K38/42;A61K35/14;
国家 US
入库时间 2022-08-21 23:15:38

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