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Paramyxovirus vector for transfering foreign gene into skeletal muscle
Paramyxovirus vector for transfering foreign gene into skeletal muscle
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机译：用于将外源基因转移到骨骼肌中的副粘病毒载体
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摘要
Whether recombinant Sendai virus (SeV) vector can be used for transporting genes into skeletal muscle was examined using LacZ reporter gene and insulin-like growth factor gene. As a result, transgene expression continued at longest for 1 month after the injection. Compared with control, the transduction of the insulin-like growth factor gene caused a significant increase in regenerated fibers and splitting myofibers, i.e., an index of hypertrophy. Furthermore, the total number or myofibers increased by the gene. Thus, Paramyxovirus vectors, including Sendai virus, were shown to achieve a high-level expression of transgenes in skeletal muscle; and the high potential of the transduction of an insulin-like growth factor gene using a Paramyxovirus vector in treating neuromuscular disorders was indicated.
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