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7 Human ovarian and ovarian cancer associated proteins

机译：7种人类卵巢癌和卵巢癌相关蛋白

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摘要

This invention relates to newly identified ovarian or ovarian cancer related polynucleotides and the polypeptides encoded by these polynucleotides herein collectively known as ovarian cancer antigens, and the use of such ovarian antigens for detecting disorders of the reproductive system, particularly the presence of ovarian cancer and ovarian cancer metastases. This invention relates to ovarian cancer antigens as well as vectors, host cells, antibodies directed to ovarian cancer antigens and the recombinant methods and synthetic methods for producing the same. Also provided are diagnostic methods for detecting, treating, preventing and/or prognosing disorders related to the ovary, including ovarian cancer, and therapeutic methods for treating such disorders. The invention further relates to screening methods for identifying agonists and antagonists of ovarian cancer antigens of the invention. The present invention further relates to inhibiting the production and function of the polypeptides of the present invention.

机译：本发明涉及新近鉴定的与卵巢或卵巢癌有关的多核苷酸以及由这些多核苷酸编码的多肽，在本文中统称为卵巢癌抗原，以及这种卵巢抗原在检测生殖系统疾病，特别是卵巢癌和卵巢癌的存在中的用途。癌症转移。本发明涉及卵巢癌抗原以及载体，宿主细胞，针对卵巢癌抗原的抗体及其重组方法和合成方法。还提供了用于检测，治疗，预防和/或预后与卵巢有关的疾病（包括卵巢癌）的诊断方法，以及用于治疗此类疾病的治疗方法。本发明进一步涉及用于鉴定本发明卵巢癌抗原的激动剂和拮抗剂的筛选方法。本发明进一步涉及抑制本发明多肽的产生和功能。

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公开/公告号US2004010121A1

专利类型
公开/公告日2004-01-15

原文格式PDF
申请/专利权人 BIRSE CHARLES E.;ROSEN CRAIG A.;
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申请/专利号US20030333900
发明设计人 CHARLES E. BIRSE;CRAIG A. ROSEN;
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申请日2003-01-24
分类号C07K14/47;
国家 US
入库时间 2022-08-21 23:19:19

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