首页>
外国专利>
Use of polyclonal human anti-hTg autoantibodies as clinical diagnostics for thyroid autoimmune diseases and additives for the detection of anti-hTg autoantibodies in patient sera
Use of polyclonal human anti-hTg autoantibodies as clinical diagnostics for thyroid autoimmune diseases and additives for the detection of anti-hTg autoantibodies in patient sera
PCT No. PCT/EP96/00514 Sec. 371 Date Oct. 17, 1997 Sec. 102(e) Date Oct. 17, 1997 PCT Filed Feb. 7, 1996 PCT Pub. No. WO96/25668 PCT Pub. Date Aug. 22, 1996Use of polyclonal human autoantibodies against thyroglobulin (anti-hTg autoantibodies), in particular in the form of an affinity-purified IgG fraction, as a specific binding reagent in an immunological assay for the clinical detection of autoantibodies against thyroglobulin (anti-hTg autoantibodies) in the serum of a patient, in particular in competitive assays in which the anti-hTg autoantibodies to be determined and present in the sample and the polyclonal human anti-hTg autoantibodies used as the specific binding reagent compete for the binding sites of a human thyroglobulin (hTg) used as a further reagent of the assay, one of the stated reagents in each case being labelled and the other component in each case being bound to a solid phase, and in which the presence of the anti-hTg autoantibodies to be determined and present in the sample is detected on the basis of the reduction of the binding of the labelled reagent to the solid phase.
展开▼
