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GUILLAIN-BARRE SYNDROME AND / OR FISHER SYNDROME-DEVELOPING MODEL NON-HUMAN ANIMAL

机译：吉兰-巴雷氏综合症和/或费雪氏综合症发展模式非人类动物

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摘要

PPROBLEM TO BE SOLVED: To provide a Guillain-Barre syndrome and / or Fisher syndrome-developing model non-human animal which can be obtained by immunizing an FcγRIIB gene-deleted non-human with ganglioside GQ1b, and to provide a method for screening a Guillain-Barre syndrome-treating medicine with the model non-human animal. PSOLUTION: This Guillain-Barre syndrome-developing model mouse is made by immunizing an FcγRIIB gene-deleted mouse with ganglioside GM1, DM2, GD1a and GQ1b for each three weeks totally four times together with a Freund's adjuvant. PCOPYRIGHT: (C)2004,JPO

机译：

要解决的问题：提供可通过用神经节苷脂GQ1b免疫FcγRIIB基因缺失的非人免疫接种而获得的Guillain-Barre综合征和/或Fisher综合征发展模型非人动物，并提供一种用模型非人类动物筛选治疗格林-巴利综合征的药物的方法。

解决方案：通过用神经节苷脂GM1，DM2，GD1a和GQ1b与弗氏佐剂一起每三周免疫Fc-RIIB基因缺失的小鼠，从而制成这种开发格林-巴利综合征的模型小鼠。

版权：（C）2004，日本特许厅展开▼

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公开/公告号JP2004147535A

专利类型
公开/公告日2004-05-27

原文格式PDF
申请/专利权人 JAPAN SCIENCE & TECHNOLOGY AGENCY;
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申请/专利号JP20020315091
发明设计人 NAKAMURA AKIRA;SUGAWARA AKIKO;YAJIMA KAORI;TAKAI TOSHIYUKI;
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申请日2002-10-29
分类号A01K67/027;C12N15/09;
国家 JP
入库时间 2022-08-21 23:33:35

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