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New heterogeneous catalysts, useful as enantioselective catalysts for processes such as cyclopropanation, Diels-Alder reactions and Mukaiyama aldol reactions, are based on derivatives of bisoxazoline
New heterogeneous catalysts, useful as enantioselective catalysts for processes such as cyclopropanation, Diels-Alder reactions and Mukaiyama aldol reactions, are based on derivatives of bisoxazoline
Chiral substituted bisoxazoline compounds (I) grafted to silica-type supports used as heterogeneous catalysts in the presence of a transition metal salt precursor. Heterogeneous catalysts comprise a bisoxazoline base of formula (I). n = 1 or 2; R1 and R2 = H, phenyl, (1-8C alkylene)phenyl or 1-8C alkyl, or may together complete a 4-10C (preferably 5C) ring to which may be condensed a benzene ring or a bicycloheptane (optionally alkyl substituted); A = a group of formula (i)-(v); R3 and R4 = 1-3C alkyl, (1-3C alkyl)phenyl or H; X = CH or N; m = 0-3; P = polymerizable monomer, a polymer or a molecule capable of attachment to a solid surface. Independent claims are also included for the preparation and use of (I).
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机译：在过渡金属盐前体的存在下，接枝到二氧化硅型载体上的手性取代双恶唑啉化合物（I）被用作多相催化剂。非均相催化剂包含式（I）的双恶唑啉碱。 n = 1或2; R 1和R 2 ＝ H，苯基，（1-8C亚烷基）苯基或1-8C烷基，或者可以一起完整地形成4-10C（优选5C）的环，可以将其稠合苯环或环。双环庚烷（任选被烷基取代）; A ＝一组式（i）-（v）; R 3和R 4 ＝ 1-3C烷基，（1-3C烷基）苯基或H; X = CH或N; m = 0-3; P ＝能够聚合到固体表面的可聚合单体，聚合物或分子。独立权利要求也包括用于（I）的制备和使用。
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