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EXPRESSION OF THE INSL4 GENE IN HUMAN EMBRYONIC BONE TISSUES AND APPLICATIONS

机译：INSL4基因在人胚骨组织中的表达及其应用

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摘要

The invention concerns the locating of the expression of the insulin-like 4 (ISNL4) gene in the human embryonic bone tissues and ligaments, detection and diagnostic methods, methods for marking and detecting said tissues expressing INSL4 gene expression products as well as methods for selecting compounds capable of modulating the activity of said cells. The invention also concerns medicines for treating pathologies related to the differentiation and/or abnormal proliferation of said tissues, particularly pathologies related to the abnormal development of the cartilage and/or an abnormal ossification of the bone being formed and/or the abnormal development of interarticular ligaments.

机译：本发明涉及人胚骨组织和韧带中胰岛素样4（ISNL4）基因表达的定位，检测和诊断方法，标记和检测所述表达INSL4基因表达产物的组织的方法以及选择方法能够调节所述细胞活性的化合物。本发明还涉及用于治疗与所述组织的分化和/或异常增殖有关的病理学，特别是与软骨的异常发展和/或所形成的骨的骨化异常和/或关节间异常发展有关的病理学的药物。韧带。

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公开/公告号FR2774095B1

专利类型
公开/公告日2002-12-13

原文格式PDF
申请/专利权人 INSTITUT GUSTAVE ROUSSY;
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申请/专利号FR19980000715
发明设计人 LAURENT ANNE;BELLET DOMINIQUE;
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申请日1998-01-23
分类号C07K14/62;C07K16/26;G01N33/68;C12Q1/68;A61K38/28;A61K39/395;A61K48/00;C07H21/00;
国家 FR
入库时间 2022-08-21 23:38:15

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