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Treatment and prevention of elevated lyso-PAF levels mediated mental illnesses with PAF antagonists
Treatment and prevention of elevated lyso-PAF levels mediated mental illnesses with PAF antagonists
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机译:用PAF拮抗剂治疗和预防溶血PAF介导的精神疾病升高
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摘要
The invention refers to the treatment of lyso-paf-mediated diseases with paf antagonists and a procedure for determining their efficacy. According to the invention for treating a disease caused by lyso paf ( 1-0-alkyl-sn-glyceryl-3-phosphocholine) as the precursor and metabolit of paf is found in elevated amounts in the liquor of mental and/or inflammatory diseases. Lyso paf regulates via its own receptor the paf receptors on human neutrophils which are then inhibited by paf antagonists. According to the invention for treating a mental and/or inflammatory diseases caused by lyso paf an effective amount of at least one paf antagonist is administered to a subject requiring said treatment, wherein the paf antagonist is a hydrophilic or non-hydrophilic triazolothieno-diazepine or a homologue thereof, a ginkgolide, a ginkgolide mixture or a synthetic ginkgolide derivate, or an analogue of the paf or a mixture with/of these compounds. IMAGE
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