首页> 外国专利> Extracellular cyclic adenosine monophosphate-dependent protein kinase in the diagnosis and prognosis

Extracellular cyclic adenosine monophosphate-dependent protein kinase in the diagnosis and prognosis

机译:细胞外环状单磷酸腺苷依赖性蛋白激酶在诊断和预后中的作用

摘要

PURPOSE: A cancer diagnosing method by using extracellular cyclic adenosine monophosphate(cAMP)-dependent protein kinase A is provided to determine various kinds of cancer besides breast cancer at an early stage and is potentially useful in the treatment and prognosis of the cancer in a patient by reducing the level of extraPKA by down-regulation, such as by delivering the RII beta subunit of PKA-II to target cancer cells. CONSTITUTION: A method of diagnosing cancer in a patient which method comprises assaying a sample from a cancer patient for the presence of extracellular cAMP-dependent protein kinase A(ECPKA), wherein the presence of an elevated level of ECPKA in sample compared to the level of cAMP-dependent extraPKA in a control sample is quantitatively indicative of cancer in the patient, the level of cAMP-dependent extraPKA in control sample is from about 0 to about 1.0mUnits/ml blood serum or urine, and the cancer is breast cancer, prostate cancer, ovarian cancer, or bladder cancer.
机译:目的:提供一种利用细胞外环状单磷酸腺苷(cAMP)依赖性蛋白激酶A的癌症诊断方法,以早期确定除乳腺癌以外的各种癌症,并且可能对患者的癌症治疗和预后有用通过下调降低ExtraPKA的水平,例如将PKA-II的RII beta亚基传递到靶癌细胞。构成:一种诊断患者癌症的方法,该方法包括分析癌症患者样品中是否存在细胞外cAMP依赖性蛋白激酶A(ECPKA),其中与水平相比,样品中ECPKA水平升高对照样品中cAMP依赖的ExtraPKA的定量表示患者患有癌症,对照样品中cAMP依赖的extraPKA的水平为血清或尿液中约0至约1.0mUnits / ml,癌症是乳腺癌,前列腺癌,卵巢癌或膀胱癌。

著录项

  • 公开/公告号KR100377378B1

    专利类型

  • 公开/公告日2003-03-28

    原文格式PDF

  • 申请/专利权人

    申请/专利号KR19990064041

  • 发明设计人 조윤숙;

    申请日1999-12-28

  • 分类号G01N33/15;

  • 国家 KR

  • 入库时间 2022-08-21 23:45:36

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