首页> 外国专利> INHALEABLE SPRAY DRIED 4-HELIX BUNDLE PROTEIN POWDERS HAVING MINIMIZED AGGREGATION

INHALEABLE SPRAY DRIED 4-HELIX BUNDLE PROTEIN POWDERS HAVING MINIMIZED AGGREGATION

机译:具有最小化聚集作用的不可喷雾喷雾干燥的4螺旋束蛋白粉

摘要

The present invention provides highly dispersible spray-dried powder compositions, and in particular, inhaleable dry powder compositions for aerosolized delivery to the lungs. The powders of the invention are produced by spray drying a 4 alpha-helix bundle protein under conditions which both (i) protect the protein from aggregation and (ii) provide particles suitable for inhalation (i.e., demonstrating superior aerosol performance).
机译:本发明提供了高度分散的喷雾干燥粉末组合物,尤其是用于雾化递送至肺的可吸入的干粉末组合物。本发明的粉末是通过在以下条件下喷雾干燥4α-螺旋束蛋白而制得的:(i)保护蛋白免于聚集和(ii)提供适合吸入的颗粒(即,显示出优异的气溶胶性能)。

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