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-72 Semi-human monoclonal antibodies binding to tumor-associated glycoprotein antigen TAG-72 and human light chain comprising the same
-72 Semi-human monoclonal antibodies binding to tumor-associated glycoprotein antigen TAG-72 and human light chain comprising the same
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机译:-72与肿瘤相关糖蛋白抗原TAG-72结合的半人单克隆抗体和包含该抗体的人轻链
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摘要
PURPOSE: Provided are semi-human monoclonal antibody binding to tumor-associated glycoprotein antigen TAG-72 and a human light chain composing the same. The semi-human monoclonal antibody has a human light chain of which amino acid sequence is completely derived from the human, therefore it is useful for the diagnosis and treatment of cancer. CONSTITUTION: The semi-human monoclonal antibody specifically binds to TAG-72 antigen of which the light chain of human antibody AKA/HzK is substituted with the light chain of a human derived antibody. Wherein the light chain of a human derived antibody is composed of amino acid sequence derived from the VK1 family of human immunoglobulin kappa light chain germline. And it is represented by the SEQ ID NO:9 and expressed from the nucleotide sequence of SEQ ID NO:14.
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机译:目的:提供与肿瘤相关糖蛋白抗原TAG-72结合的半人单克隆抗体和组成其的人轻链。半人单克隆抗体具有其氨基酸序列完全来源于人的人轻链,因此可用于癌症的诊断和治疗。组成:半人单克隆抗体特异性结合TAG-72抗原,其人抗体AKA / HzK的轻链被人源抗体的轻链取代。其中,人源抗体的轻链由人源免疫球蛋白κ轻链种系的VK1家族衍生的氨基酸序列组成。并且由SEQ ID NO:9表示,并由SEQ ID NO:14的核苷酸序列表达。
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