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MICE HETEROZYGOUS FOR WFS1 GENE AS MOUSE MODELS FOR DEPRESSION
MICE HETEROZYGOUS FOR WFS1 GENE AS MOUSE MODELS FOR DEPRESSION
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机译:WFS1基因的小鼠杂合子作为抑郁症的小鼠模型
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摘要
The present invention describes a recombinant rodent model for depression. More particularly, the rodent comprises cells expressing mutations in the WFS1 gene. The rodent is preferably a mouse heterologous for mutations in exon 8 of the WFS1 gene. Preferably, the mutations yield a non-functional wolframin protein that lacks all or some of it transmembrane regions. Methods and compositions for making and using the mouse and cells thereof are disclosed.
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