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Modulation of TH1/TH2 cytokine expression by ribavirin and ribavirin analogs in activated t-lymphocytes
Modulation of TH1/TH2 cytokine expression by ribavirin and ribavirin analogs in activated t-lymphocytes
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机译：病毒唑和病毒唑类似物在活化的t淋巴细胞中对TH1 / TH2细胞因子表达的调节
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摘要
Ribavirin is administered to a patient in a dosage range which is effective to modulate lymphokine expression in activated T cells. In particular, Ribavirin is used to suppress Th2-mediated T cell responses and promote Th1 -mediated T cell responses. In other aspects of the invention, one or more Ribavirin analogs are administered to a patient in a dosage range which is effective to modulate lymphokine expression in activated T cells. The Ribavirin analog(s) may be used to suppress or enhance Th1 or Th2-mediated T cell responses in a viral (e.g. human immunodeficiency virus, hepatitis C virus) and non viral disease (e.g. allergy, autoimmune diseases, helminthic disease, leishmaniasis).
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