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(R)-2,3-butanediol dehydrogenase, methods for producing same, and methods for producing optically active alcohol using the dehydrogenase
(R)-2,3-butanediol dehydrogenase, methods for producing same, and methods for producing optically active alcohol using the dehydrogenase
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机译：（R）-2，3-丁二醇脱氢酶，其制备方法和使用该脱氢酶制备旋光醇的方法
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摘要
The object of the present invention is to provide an (R)-2,3-butanediol dehydrogenase which uses NADH as a coenzyme, and methods for producing optically active alcohols and ketones using the enzyme. The inventors of the present invention discovered a novel (R)-2,3-butanediol dehydrogenase, isolated a DNA encoding the dehydrogenase, and produced recombinants that express the dehydrogenase at high levels. The dehydrogenase is produced by and can be isolated and purified from Kluyveromyces lactis. The use of the dehydrogenase of the invention enables efficient production of (R)-1,3-butanediol with high optical purity from 4-hydroxy-2-butanone. Also provided by the present invention are methods for efficiently producing (S)-1,3-butanediol with high optical purity from racemic 1,3-butanediol, as well as 4-hydroxy-2-butanone from (R)-1,3-butanediol.
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