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首页> 外国专利> DERIVATIVES 0F N,S-SUBSTITUTIONS N'-1 (HETERO)ARYL ALKYL-N'-HETERO) ARYL METHYL ISOTHIOUREAS, METHOD FOR PRODUCING SALTS AND BASES THEREOF, PHYSIOLOGICALLY ACTIVE N,S-SUBSTITUTIONS N'-1 (HETERO)ARYL ALKYL-N'-HETERO) ARYL METHYL ISOTHIOUREAS, A PHARMACEUTICAL COMPOSITION AND CURING METHOD

DERIVATIVES 0F N,S-SUBSTITUTIONS N'-1 (HETERO)ARYL ALKYL-N'-HETERO) ARYL METHYL ISOTHIOUREAS, METHOD FOR PRODUCING SALTS AND BASES THEREOF, PHYSIOLOGICALLY ACTIVE N,S-SUBSTITUTIONS N'-1 (HETERO)ARYL ALKYL-N'-HETERO) ARYL METHYL ISOTHIOUREAS, A PHARMACEUTICAL COMPOSITION AND CURING METHOD

机译：衍生物0F N，S取代基N'-1 [（杂）芳基]烷基-N'-[杂芳基]甲基异硫氰酸盐，其生产盐和碱的方法，具有生理活性的N，S取代基N'-1 [ （杂）芳基]烷基-N'-[杂）芳基甲基异硫脲，药物成分和制备方法

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摘要

The inventive derivatives of N,S-substitutions N'-1 [(hetero)aryl] alkyl-N'-[hetero) aryl] methyl isothioureas including bases and salts thereof with pharmacologically acceptable acids and individual optical isomers of said compositions or the mixtures thereof are represented by the following general formula (I): where R?1, R2, R3¿, X,Y and Z have the values detailedly defined in the description thereof. The inventive compositions exhibit the properties of efficient neuroprotectors-blockers of the glutamate-induced transport of calcium ions. The inventive methods for producing said compositions, including stable bases and optical isomers thereof are also disclosed. The inventive physiologically active compositions of the formula (I) embodied in the form of the efficient neuroprotectors-blockers of the glutamate-induced transport of calcium ions and the method for producing a glutamatergic system with the aid thereof are also disclosed. The inventive method for curing several diseases (including Alzheimer's disease and Huntingdon's chorea) consists in prescribing to patients an efficient quantity of the formula (I) compositions. The inventive pharmaceutical compositions containing the therapeutically acceptable quantity of the composition (I) and acceptable inert auxiliary agents are also disclosed.
机译：N，S-取代N'-1 [（杂）芳基]烷基-N'-[杂）芳基]甲基异硫脲的衍生物，包括其碱和与药学上可接受的酸的盐和所述组合物或混合物的单独的旋光异构体其通式（I）由以下通式表示：其中R 1，R 2，R 3，X，Y和Z具有在其说明书中详细定义的值。本发明的组合物表现出谷氨酸诱导的钙离子转运的有效神经保护剂-阻断剂的性质。还公开了生产所述组合物的本发明方法，所述组合物包括稳定的碱及其旋光异构体。还公开了以谷氨酸诱导的钙离子运输的有效神经保护剂-阻断剂的形式体现的本发明的式（I）的生理活性组合物，以及借助其的制备谷氨酸能系统的方法。治愈几种疾病（包括阿尔茨海默氏病和亨廷顿舞蹈病）的本发明方法在于向患者开出有效量的式（I）组合物。还公开了含有治疗上可接受量的组合物（I）和可接受的惰性助剂的本发明药物组合物。

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