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INCREASED FUNCTIONAL ACTIVITY AND/OR EXPRESSION OF ABC TRANSPORTERS PROTECTS AGAINST THE LOSS OF DOPAMINE NEURONS ASSOCIATED WITH PARKINSON'S DISEASE
INCREASED FUNCTIONAL ACTIVITY AND/OR EXPRESSION OF ABC TRANSPORTERS PROTECTS AGAINST THE LOSS OF DOPAMINE NEURONS ASSOCIATED WITH PARKINSON'S DISEASE
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机译：功能性活性和/或ABC转运蛋白对帕金森氏病引起的多巴胺神经元丢失的保护作用增强
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摘要
Methods and compositions are provided for reducing the level of a catecholamine, in particular dopamine, and conjugates thereof, thus reducing catecholaminergic cell toxicity, by increasing a functional activity or increasing expression of ABC transporter polypeptides. ABC transporters serve to extrude dopamine and dopamine conjugates out of the neuron, thus preventing or reducing dopamine-associated toxicity, including cell death. Agents that increase a level of expression, or increase a functional activity, or increase both, of the ABC transporters find utility in preventing or alleviating Parkinson's disease.
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