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METHODS AND COMPOSITIONS TO UPREGULATE, REDIRECT OR LIMIT IMMUNE RESPONSES TO BIOACTIVE COMPOUNDS

机译:上调,重新定向或限制对生物活性化合物的免疫反应的方法和成分

摘要

Novel compositions are disclosed which can induce or enhance an immune response against foreign or self antigens (microbial or parasitic) or modulate (that can lead to suppression) the activity of pathogenic cells in inflammatory or autoimmune diseases. Compositions and methods are taught in how to limit the generation of an immune response against formulated peptides and proteins with application in antibody therapy or hormone replacement therapy. Methods of suppressing autoimmunity are also disclosed which use ligands for cellular receptors expressed on cells of the innate immune system and more specifically for down-regulation of autoimmune processes by either deletion or induction of anergy at the level of autoreactive T cells or by triggering active-suppressor T cells that down-regulate the activity of pathogenic cells.
机译:公开了可以诱导或增强针对外源或自身抗原(微生物或寄生虫)的免疫应答或调节(可导致抑制)炎性或自身免疫性疾病中病原细胞的活性的新型组合物。教导了如何在抗体疗法或激素替代疗法中应用以限制对配制的肽和蛋白质的免疫应答的产生的组合物和方法。还公开了抑制自身免疫的方法,该方法使用先天免疫系统细胞上表达的细胞受体配体,更具体地说,通过在自身反应性T细胞水平上缺失或诱导无能或通过触发活性抗原来下调自身免疫过程。下调病原细胞活性的抑制性T细胞。

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