首页> 外国专利> MEDICAL DEVICES FOR DELIVERING ANTI-PROLIFERATIVE COMPOSITIONS TO ANATOMICAL SITES AT RISK FOR RESTENOSIS

MEDICAL DEVICES FOR DELIVERING ANTI-PROLIFERATIVE COMPOSITIONS TO ANATOMICAL SITES AT RISK FOR RESTENOSIS

机译:将具有抗增殖作用的组合物递送到解剖部位的医疗设备面临再造风险

摘要

Methods, compositions and devices for inhibiting restenosis are provided. Specifically, molecular chaperone inhibitor compositions and medical devices useful for the site specific delivery of molecular chaperones are disclosed. In one embodiment the medical device is a vascular stent coated with a molecular chaperone inhibitor selected from the group consisting of geldanamycin, herbimycin, macbecin and derivatives and analogues thereof. In another embodiment an injection catheter for delivery and an anti-restenotic effective amount of geldanamycin to the adventitia is provided.
机译:提供了抑制再狭窄的方法,组合物和装置。具体地,公开了用于分子伴侣的位点特异性递送的分子伴侣抑制剂组合物和医疗装置。在一个实施方案中,该医疗装置是一种涂覆有分子伴侣抑制剂的血管支架,该分子伴侣抑制剂选自格尔德霉素,除草霉素,马贝霉素及其衍生物和类似物。在另一个实施方案中,提供了用于向外膜递送的注射导管和抗再狭窄有效量的格尔德霉素。

著录项

  • 公开/公告号AU2003220390A1

    专利类型

  • 公开/公告日2003-10-08

    原文格式PDF

  • 申请/专利权人 MEDTRONIC AVE INC.;

    申请/专利号AU20030220390

  • 申请日2003-03-18

  • 分类号A61F2/06;

  • 国家 AU

  • 入库时间 2022-08-21 23:56:51

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