首页> 外国专利> A method and compositions for conferring viral immunity and reversing viral pathogenesis via strategic infection with a theravirus thereby providing genomic integration of genetically engineered, replication incompetent, integrating viral dna

A method and compositions for conferring viral immunity and reversing viral pathogenesis via strategic infection with a theravirus thereby providing genomic integration of genetically engineered, replication incompetent, integrating viral dna

机译：一种通过病毒疗法的战略性感染赋予病毒免疫力和逆转病毒发病机理的方法和组合物，从而提供基因工程整合的基因工程，复制能力差，整合病毒脱氧核糖核酸

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摘要

The present invention provides a method of conferring viral immunity and/or reversing viral pathogenesis via strategic genomic integration of a genetically engineered replication incompetent vDNA composition, ie., a theravirus. The invention is generally effectuated by administering to a host a therapeutic amount of genetically engineered viral DNA (vDNA) composition in an amount sufficient to out-compete the natural pathogenic vDNA's ability to integrate into the host cells genome. The genetically engineered vDNA construct is genetically altered in a manner that effectively prevents post integration transcription of the composition. The invention is effective in the prevention and treatment of viral infections, including, HIV (AIDS), herpes and hepatitis.

机译：本发明提供了通过基因工程复制不适合的vDNA组合物，即治疗病毒的策略性基因组整合，赋予病毒免疫力和/或逆转病毒发病机理的方法。通常通过向宿主施用治疗量的遗传工程病毒DNA（vDNA）组合物来实现本发明，该组合物的量应足以胜过天然病原性vDNA整合入宿主细胞基因组的能力。基因工程的vDNA构建体以有效防止组合物的后整合转录的方式进行了遗传改变。本发明有效地预防和治疗包括HIV（AIDS），疱疹和肝炎在内的病毒感染。

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公开/公告号AU2002364958A8

专利类型
公开/公告日2003-07-09

原文格式PDF
申请/专利权人 GLACER LAWRENCE F.;
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申请/专利号AU20020364958
发明设计人 LAWRENCE F. GLACER;
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申请日2002-11-19
分类号A61K39/21;C12N7/01;C12N15/00;C12N15/07;C12N15/09;C12N15/40;C12N15/48;
国家 AU
入库时间 2022-08-21 23:57:21

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