首页> 外国专利> PREPARATION OF TRANS-FUSED 3,3A,8,12B-TETRAHYDRO-2PREPARATION OF TRANS-FUSED 3,3A,8,12B-TETRAHYDRO-2PREPARATION OF TRANS-FUSED 3,3A,8,12B-TETRAHYDRO-2H-DIBENZO3,4:6,7CYCLOHEPTA1,2-BFURAN DERIVATIVH-DIBENZOÝ3,4:6,7¨CYCLOHEPTAÝ1,2-B¨FURAN DERIVATIVH-DIBENZOÝ3,4:6,7¨CYCLOHEPTAÝ1,2-B¨FURAN DERIVATIVES ES ES

PREPARATION OF TRANS-FUSED 3,3A,8,12B-TETRAHYDRO-2PREPARATION OF TRANS-FUSED 3,3A,8,12B-TETRAHYDRO-2PREPARATION OF TRANS-FUSED 3,3A,8,12B-TETRAHYDRO-2H-DIBENZO3,4:6,7CYCLOHEPTA1,2-BFURAN DERIVATIVH-DIBENZOÝ3,4:6,7¨CYCLOHEPTAÝ1,2-B¨FURAN DERIVATIVH-DIBENZOÝ3,4:6,7¨CYCLOHEPTAÝ1,2-B¨FURAN DERIVATIVES ES ES

机译：制备转熔3,3A，8,12B-四氢-2制备转熔3,3A，8,12B-四氢-2制备转熔3,3A，8,12B-四氢-2H-二苯并[3] ，4：6,7] CYCLOHEPTA [1,2-B] FURANDERIVATIVH-DIBENZOÝ3,4：6,7¨CYCLOHEPTAÝ1,2-B¨FURANDERIVATIVH-DIBENZOÝ3,4：6,7，CYCLOHEPTAÝ1,2-B¨FURAN衍生品ES ES

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摘要

The present invention concerns processes for the preparation of each of the 4 diastereomers of formula (I): in stereochemically pure form from either of t wo enantiomerically pure precursors. The tetracyclic ringsystem having trans- fused five and seven membered rings is formed in an acid-catalysed cyclizati on reaction. The invention further relates to the thus obtained cis-fused tetracyclic alcohol intermediates, the methanamine end-products, the methanamine end-products for use as a medicine, in particular as CNS active medicines.

机译：本发明涉及由两种对映体纯前体中的任一种以立体化学纯形式制备式（I）的4种非对映体中的每一种的方法。在反应过程中，在酸催化的环化反应中形成了具有五个和七个成员环的四环环氧基的四环体系。本发明还涉及这样获得的顺式稠合的四环醇中间体，用作药物，特别是用作CNS活性药物的甲胺最终产物，甲胺最终产物。

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公开/公告号CA2468038A1

专利类型
公开/公告日2003-06-12

原文格式PDF
申请/专利权人 JANSSEN PHARMACEUTICA NAAMLOZE VENNOOTSCHAP;
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申请/专利号CA20022468038
发明设计人 COMPERNOLLE FRANS JOSEF CORNELIUS;KOZLECKI TOMASZ;LANG YOLANDE LYDIA;MEDAER BART PETRUS ANNA MARIA JOZEF;HOORNAERT GEORGES JOSEPH CORNELIUS;BROSSETTE THIERRY;GUILLAUME MICHEL JOSEPH MAURICE ANDRE;MAO HUA;
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申请日2002-12-02
分类号C07D307/93;A61K31/34;
国家 CA
入库时间 2022-08-21 23:58:07

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