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Methods and compositions for sensitive, rapid and functional identification of genomic polynucleotides, and their use for cellular assays in the development of drugs.
Methods and compositions for sensitive, rapid and functional identification of genomic polynucleotides, and their use for cellular assays in the development of drugs.
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机译：用于灵敏，快速和功能性鉴定基因组多核苷酸的方法和组合物，及其在药物开发中用于细胞测定的用途。
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摘要
The present invention relates to methods and compositions for identifying proteins that modulate OR CHEMICAL directly and indirectly a polynucleotide GENOMIC, AND PROCEDURES IDENTIFICATION active genomic polynucleotides. IN GENERAL, the procedure involves inserting a expression construct BL (BETA lactamase) in a genome eukaryotic, usually without yeast, which contains at least one cell alive, contact the cell having a predetermined concentration A MODULATOR AND ACTIVITY DETECTED BL in the cell.
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