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Phosphate mimics and methods of treatment using phosphatase inhibitors.

机译:磷酸盐模拟物和使用磷酸酶抑制剂的治疗方法。

摘要

The invention relates to trifluoromethyl sulfonyl and trifluoromethyl sulfonamido compounds and the physiologically acceptable salts and the prodrugs thereof. These compounds are expected to modulate the activity of protein tyrosine enzymes which are related to cellular signal transduction, in particular, protein tyrosine phosphatase, and therefore are expected to be useful in the prevention and treatment of disorders associated with abnormal protein tyrosine enzyme related cellular signal transduction such as cancer, diabetes, immuno-modulation, neurologic degenerative diseases, osteoporosis and infectious diseases. The invention also relates to the use of compounds containing fluoromethyl sulfonyl groups as phosphate mimics. These mimics may be used to inhibit, regulate or modulate the activity of a phosphate binding protein in a cell.
机译:本发明涉及三氟甲基磺酰基和三氟甲基磺酰胺基化合物及其生理上可接受的盐和前药。这些化合物有望调节与细胞信号转导有关的蛋白质酪氨酸酶的活性,特别是蛋白质酪氨酸磷酸酶的活性,因此有望用于预防和治疗与蛋白质酪氨酸酶相关的细胞信号异常有关的疾病。转导,例如癌症,糖尿病,免疫调节,神经退行性疾病,骨质疏松和传染病。本发明还涉及含有氟甲基磺酰基的化合物作为磷酸盐模拟物的用途。这些模拟物可用于抑制,调节或调节细胞中磷酸盐结合蛋白的活性。

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