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FUNCTIONAL COMPLEXES OF TERPYRIDINE METALS PROCESSES FOR THEIR PREPARATION AND OLIGONUCLEOTIDE CONJUGATES WITH TERPYRIDINE METAL COMPLEXES
FUNCTIONAL COMPLEXES OF TERPYRIDINE METALS PROCESSES FOR THEIR PREPARATION AND OLIGONUCLEOTIDE CONJUGATES WITH TERPYRIDINE METAL COMPLEXES
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机译:萜类金属金属的功能配合物及其与萜类金属配合物的寡核苷酸缀合物的制备
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PCT No. PCT/EP95/03409 Sec. 371 Date Jul. 28, 1997 Sec. 102(e) Date Jul. 28, 1997 PCT Filed Aug. 30, 1995 PCT Pub. No. WO96/07668 PCT Pub. Date Mar. 14, 1996The present invention relates to cyclic terpyridine-lanthanide complexes having 8 nitrogen atoms and 10 carbon atoms in the macrocycle and containing a functional group in the terpyridine moiety. The invention also relates to a process for the preparation of cyclic terpyridine-lanthanide complexes through the condensation of terpyridine hydrazines with pyridine-2,6-dialdehydes or -ketones. The compounds can be complexed with oligonculeotides and are useful in the sequence-specific cleavage of RNA.
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