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A permanent skin replacement comprising allogenic epithelial cells cultured in vitro and autologous epithelial cells
A permanent skin replacement comprising allogenic epithelial cells cultured in vitro and autologous epithelial cells
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机译：永久性皮肤置换，包括体外培养的同种异体上皮细胞和自体上皮细胞
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摘要
Skin replacements to aid wound healing are described. In one embodiment, the living skin replacement is chimeric and is produced by seeding autologous epithelial cells onto a biocompatible substrate containing allogeneic epithelial cells cultured in vitro. The living chimeric skin replacement may be implanted over a permanent dermal replacement previously implanted at the wound site. In another embodiment the skin replacement is a composite comprising an inner, middle and outer component, comprising (a) an inner component comprising a biocompatible dermal construct having a biodegradable or removable scaffold as a base; (b) a middle component comprising epithelial cells; and (c) an outer component comprising epithelial cells cultured in vitro on a dermal construct comprising a dermal portion having a biodegradable or removable scaffold as a base, the dermal portion being combined with a transitional covering and facing inward toward the middle component of epithelial cells. Further described are methods of making the various skin replacements.
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