• 主题
高级搜索  >
历史搜索 清空历史
首页> 外国专利> Novel tricyclic compounds and their use in medicine, a process for their preparation, pharmaceutical compositions containing them, and their use in the manufacture of a medicament for treating diseases in which insulin is the underlying pathophysiological mechanism

Novel tricyclic compounds and their use in medicine, a process for their preparation, pharmaceutical compositions containing them, and their use in the manufacture of a medicament for treating diseases in which insulin is the underlying pathophysiological mechanism

机译：新型三环化合物及其在医学中的用途，其制备方法，包含它们的药物组合物及其在制备用于治疗以胰岛素为根本病理生理机制的疾病的药物中的用途

页面导航
  • 摘要
  • 著录项
  • 相似文献

摘要

Novel hypolipidemic, antihyperglycemic compounds of formula (I) and its compositions wherein: R1, R2, R3 and R4 are the same or different and represent hydrogen, halogen, hydroxy, nitro, cyano, formyl or optionally substituted groups as described in the complete specification; Ring A represents a 5-6 membered carbocyclic structure which may optionally be substituted and may be saturated or contain one or more double bonds or may be aromatic; X represents a heteroatom selected from oxygen, sulfur, or NR9 where R9 is hydrogen, alkyl, aryl, aralkyl, acyl, alkoxycarbonyl, aryloxycarbonyl or aralkoxycarbonyl; Ar represents an optionally substituted divalent single or fused aromatic or heterocyclic group; R5 represents hydrogen, hydroxy, alkoxy, halogen, lower alkyl, optionally substituted aralkyl group or forms a bond together with the adjacent R6; R6 represents hydrogen, hydroxy, alkoxy, halogen, lower alkyl group, acyl, optionally substituted aralkyl or forms a bond with R5; R7 represents hydrogen, or a optionally substituted group as described in the complete specification; R8 represents hydrogen or an optionally substituted group as described in the complete specification; Y represents oxygen or NR10 where R10 represents hydrogen, alkyl, aryl, hydroxyalkyl or aralkyl groups or R8 and R10 together form a 5 or 6 membered cyclic structure containing carbon atoms which may optionally contain one or more heteroatoms selected from oxygen, sulfur or nitrogen; n is an integer ranging from 1-4 and m is an integer 0 or 1.
机译：式（I）的新型降血脂，降血糖化合物及其组合物，其中：R1，R2，R3和R4相同或不同，并代表氢，卤素，羟基，硝基，氰基，甲酰基或任选取代的基团，如完整说明书中所述;环A代表5-6元碳环结构，其可以任选地被取代并且可以是饱和的或包含一个或多个双键或可以是芳族的; X代表选自氧，硫或NR 9的杂原子，其中R 9为氢，烷基，芳基，芳烷基，酰基，烷氧羰基，芳氧羰基或芳烷氧羰基; Ar表示任选取代的二价单或稠合芳族或杂环基; R5代表氢，羟基，烷氧基，卤素，低级烷基，任选取代的芳烷基或与相邻的R6一起形成键; R6代表氢，羟基，烷氧基，卤素，低级烷基，酰基，任选取代的芳烷基或与R5形成键; R 7代表氢或完整说明书中所述的任选取代的基团; R 8代表氢或整个说明书中所述的任选取代的基团; Y代表氧或NR 10，其中R 10代表氢，烷基，芳基，羟烷基或芳烷基，或R 8和R 10一起形成含有碳原子的5或6元环状结构，该碳原子可任选地包含一个或多个选自氧，硫或氮的杂原子; n为1-4的整数，m为0或1的整数。

著录项

相似文献

  • 专利
  • 外文文献
  • 中文文献
获取专利

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号