首页> 外国专利> Compound, pharmaceutical composition, process for producing a pharmaceutical composition, methods for eliciting an estrogen receptor modulation effect in a mammal, for the treatment or prevention of osteoporosis, postmenopause in a female, and for the treatment or prevention of a disorder

Compound, pharmaceutical composition, process for producing a pharmaceutical composition, methods for eliciting an estrogen receptor modulation effect in a mammal, for the treatment or prevention of osteoporosis, postmenopause in a female, and for the treatment or prevention of a disorder

机译：化合物，药物组合物，制备药物组合物的方法，在哺乳动物中引起雌激素受体调节作用，用于治疗或预防骨质疏松症，在女性中绝经后以及用于治疗或预防疾病的方法

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摘要

"COMPOSITION, PHARMACEUTICAL COMPOSITION, PROCESS FOR THE PRODUCTION OF A PHARMACEUTICAL COMPOSITION, METHODS FOR ELICATING AN EFFECT OF THE MUSFEMA FOR THE PREPARATION OF THE FEMOUS AND THE PREPOSE OF THE FEMOUS AND THE FEMALE OF THE FEMALE AND THE FEMALE OF THE FEMALE SEX TREATMENT OR PREVENTION OF A DISORDER ". The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the present invention are estrogen receptor binders and as such may be useful for treating or preventing a variety of conditions related to estrogen functioning including: bone loss, bone fractures, osteoporosis, cartilage degeneration, endometriosis, disease. uterine fibroid, burns, increased LD1 levels, cholesterol, cardiovascular disease, cognitive impairment, degenerative brain disorders, restenosis, gynecomastia, vascular smooth muscle cell proliferation, obesity, incontinence, and cancer, particularly breast, uterus and prostate.

机译：“组成，药物成分，生产药物成分的过程，说明穆斯菲玛对女性和女性的准备以及女性和女性性治疗或女性的影响的方法预防疾病”。本发明涉及化合物及其衍生物，其合成及其作为雌激素受体调节剂的用途。本发明的化合物是雌激素受体结合剂，因此可用于治疗或预防与雌激素功能有关的多种病症，包括：骨质流失，骨折，骨质疏松，软骨变性，子宫内膜异位，疾病。子宫肌瘤，烧伤，LD1水平升高，胆固醇，心血管疾病，认知障碍，脑退行性疾病，再狭窄，女性乳房发育，血管平滑肌细胞增殖，肥胖，失禁和癌症，尤其是乳腺癌，子宫癌和前列腺癌。

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公开/公告号BR0114689A

专利类型
公开/公告日2003-07-01

原文格式PDF
申请/专利权人 MERCK & CO. INC.;
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申请/专利号BR20010114689
发明设计人
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申请日2001-10-15
分类号A61K31/395;A61K31/055;A61K31/445;A61K31/40;A61P5/00;C07D405/00;C07D409/00;C07D205/00;C07D213/02;C07D411/00;
国家 BR
入库时间 2022-08-22 00:03:49

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