首页> 外国专利> Pyrimidine derivative, process for preparing a pharmaceutical composition pyrimidine derivative, use of a pyrimidine derivative, and method for producing a cell cycle inhibitory effect, anti-cancer (anti-cell proliferation) and / or a fak inhibitory effect (cellular anti-migration and / or apoptosis inducer) in a warm-blooded animal

Pyrimidine derivative, process for preparing a pharmaceutical composition pyrimidine derivative, use of a pyrimidine derivative, and method for producing a cell cycle inhibitory effect, anti-cancer (anti-cell proliferation) and / or a fak inhibitory effect (cellular anti-migration and / or apoptosis inducer) in a warm-blooded animal

机译：嘧啶衍生物，制备药物组合物嘧啶衍生物的方法，嘧啶衍生物的用途以及产生细胞周期抑制作用，抗癌（抗细胞增殖）和/或fak抑制作用（细胞抗迁移和抑制）的方法/或凋亡诱导剂）在温血动物中

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"PYRIMIDINE DERIVATIVE, PROCESS TO PREPARE A PHYRAMIDINE PHARMACEUTICAL COMPOSITION, USE OF A PYRIMIDINE DERIVATIVE, AND METHOD TO PRODUCE A CELL CYCLE IMPELLER EFFECT (ANTI-CELL AND EFFECT) FAK (CELL ANTI-MIGRATION AND / OR APOPTOSIS INDUCER) IN A HOT BLOOD ANIMAL ". The pyrimidine derivatives of formula (1) wherein Q1-, Q2-, G and R2 are as defined herein and their pharmaceutically acceptable salts and in vivo hydrolysable esters are described. Processes for their manufacture, pharmaceutical compositions and their use as cyclin-dependent serine / threonine kinase (CDK) and focal adhesion kinase (FAK) inhibitors are also described.

机译：“嘧啶衍生物，制备吗啡药的药物组合物的过程，使用嘧啶衍生物，以及产生细胞周期叶轮效应（反细胞和效应）FAK（细胞抗迁移和/或凋亡）的方法动物”。描述了其中Q 1，Q 2，G和R 2如本文所定义的式（1）的嘧啶衍生物及其药学上可接受的盐和体内可水解的酯。还描述了其制造方法，药物组合物及其作为细胞周期蛋白依赖性丝氨酸/苏氨酸激酶（CDK）和粘着斑激酶（FAK）抑制剂的用途。

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公开/公告号BR0108879A

专利类型
公开/公告日2003-04-29

原文格式PDF
申请/专利权人 ASTRAZENECA AB.;
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申请/专利号BR20010108879
发明设计人 ELIZABETH JANET PEASE;EMMA JANE WILLIAMS;ROBERT HUGH BRADBURY;STUART ERIC PEARSON;
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申请日2001-02-26
分类号C07D239/48;C07D403/12;
国家 BR
入库时间 2022-08-22 00:03:52

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