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Method of dissolving preformed amp;bgr;-amyloid peptide fibrils in vitro by poly-lysine
Method of dissolving preformed amp;bgr;-amyloid peptide fibrils in vitro by poly-lysine
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机译：聚赖氨酸体外溶解预制β淀粉样蛋白原纤维的方法
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摘要
Beta-amyloid peptide (&bgr;A) is a major fibrillar component of neuritic plaques in Alzheimer's disease (AD) brains and is related to the pathogenesis of the disease. The present invention provides a method using Poly-L-Lysine to dissolve preformed &bgr;A fibrils in vitro. Its efficiency is instantaneous. Poly-L-Lysine offers the simplest and most effective way to dissolve preformed &bgr;A fibrils. The method of this present invention can be used as a universal dissolver of all types of oligomeric &bgr;-sheet conformation, precursor of the fibrils. Poly-L-Lysine may also be useful as a future universal therapeutic agent to prevent and/or retard amyloidogenesis in vivo AD and other types of amyloid related disorders.
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机译：β-淀粉样肽（A）是阿尔茨海默氏病（AD）大脑中神经斑块的主要原纤维成分，并且与该疾病的发病机理有关。本发明提供了一种使用聚- L -赖氨酸在体外溶解预制的βA原纤维的方法。它的效率是瞬时的。聚- L -赖氨酸为溶解预制的＆bgr; A原纤维提供了最简单，最有效的方法。本发明的方法可以用作所有类型的低聚物-薄片构象的原纤的通用溶解剂。聚- L -赖氨酸也可用作预防和/或延缓体内AD和其他类型淀粉样蛋白相关疾病的淀粉样蛋白生成的未来通用治疗剂。
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