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Modulation of chromosome function by chromatin remodeling agents

机译：染色质重塑剂对染色体功能的调节

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摘要

The present invention concerns a process for modulating the function of a DNA element in a eukaryotic cell, comprising the step of contacting a genomic DNA element, so-called “chromatin responsive element” (CRE), with a compound having a molecular weight of less than approximately 5 KDa, and having the capacity to bind in a_sequence-specific manner to said CRE, said step of contacting being carried out in conditions permitting chromatin remodeling of the CRE by said compound, wherein said chromatin remodeling of the CRE alters the activity of one or more other DNA elements, so called “modulated DNA elements” in the genome.

机译：本发明涉及一种在真核细胞中调节DNA元件功能的方法，该方法包括使基因组DNA元件，即所谓的“染色质反应元件”与DNA接触的步骤。（CRE），具有小于约5 KDa的分子量并且具有以序列特异性方式结合到所述CRE的能力的化合物，所述接触步骤在允许所述CRE的染色质重塑的条件下进行。化合物，其中所述CRE的染色质重塑改变了一种或多种其他DNA元件（所谓的“调节的DNA元件”）的活性。在基因组中。

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公开/公告号US2003157715A1

专利类型
公开/公告日2003-08-21

原文格式PDF
申请/专利权人 LAEMMLI ULRICH;
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申请/专利号US20010892085
发明设计人 ULRICH LAEMMLI;
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申请日2001-06-26
分类号C12N15/87;
国家 US
入库时间 2022-08-22 00:10:15

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