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Bone Morphogenetic Protein-2 And Bone Morphogenetic Protein-4 In The Treatment And Diagnosis Of Cancer
Bone Morphogenetic Protein-2 And Bone Morphogenetic Protein-4 In The Treatment And Diagnosis Of Cancer
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机译：骨形态发生蛋白2和骨形态发生蛋白4在癌症的治疗和诊断中的作用
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摘要
The present invention pertains to the use of BMP-2 and/or BMP-4 as 1) targets for cancer treatment therapies and 2) means to diagnose cancer. The therapeutic component of this invention involves administering to a patient a composition that inhibits bone morphogenetic protein-2 activity and/or bone morphogenetic protein-4 activity. Such inhibition may be accomplished by ligands or antibodies that bind to BMP-2 and/or BMP-4 or receptors for BMP-2 and BMP-4. It may also be achieved by preventing the processing of pro-BMP-2 and/or pro-BMP-4, or blocking transcription or replication of BMP-2 DNA and/or BMP-4 DNA or translation of BMP-2 mRNA and/or BMP-4 mRNA. The diagnostic component of the invention involves measuring the BMP-2 and/or BMP-4 level(s) in biological samples from both a patient and a non-cancerous subject and comparing those levels. Elevated levels of BMP-2 and/or BMP-4 in the patient compared to the subject indicate cancer.
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