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Use of monoclonal antibodies and functional assays for prediction of risk of opportunistic infection

机译:单克隆抗体和功能分析在预测机会性感染风险中的应用

摘要

The present invention is drawn to methods of detecting and monitoring a subject at risk for opportunistic infection. More particularly, the methods comprise monitoring key monocyte functions and surrogate cell surface markers on monocytes to predict subjects at risk for opportunistic infection. Specific monocyte key functions comprise measurements of phagocytic activity and transendothelial migration. Another aspect of the present invention is a kit comprising the compositions of the present invention used to detect or monitor a subject at risk for opportunistic infection.
机译:本发明涉及检测和监测处于机会感染风险中的受试者的方法。更具体地,该方法包括监测关键的单核细胞功能和替代单核细胞上的细胞表面标记以预测处于机会感染风险中的受试者。特定的单核细胞关键功能包括吞噬活性和跨内皮迁移的测量。本发明的另一方面是试剂盒,其包含用于检测或监测有机会感染风险的受试者的本发明的组合物。

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