Devices and methods for amplifying weak electric signals are described. The device of the invention includes an amplifier that is fully integrated in a standard CMOS process and is capable of rejecting large DC offsets while amplifying signals down to the sub-Hz range. This result is achieved by using single-transistor MOS “pseudo-resistor” elements to achieve a very low cutoff frequency in the mHz range or lower. When combined with an electrode array or other sensor array, the fully-integrated amplifier is suitable for recording biological and biopotential signals from the mhz range up to and including about 7 kHz. The amplifier also rejects dc offsets at the input and offers a superior power-noise tradeoff than other amplifiers currently available.
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