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Satisfactory tablet null of feel inside

机译:令人满意的平板电脑内部没有感觉

摘要

PURPOSE: To obtain an oil and fat-containing tablet rapidly disintegrating in an oral cavity, having smoothness without roughness, excellent in touch in an oral cavity. ;CONSTITUTION: This tablet contains both a first granule comprising oils and fats and an excipient as essential components and a second granule comprising an excipient as an essential component but not fats and oils and is obtained by compression molding. The excipient is a water-soluble saccharide such as a monosaccharide, an oligosaccharide, a sugar alcohol, etc., and its amount is 70-93wt.% based on the whole first granule and 85-97wt.% based on the whole tablet. The oils and fats are solid at a normal temperature, have 30-37°C melting point or are mixed with the excipient to show 30-37°C melting point and are vegetable oils and fats (e.g. corn oil), animal oils and fats (e.g. cream) and hard fats. The amount of the oils and fats contained is 70-30wt.% based on the whole first granule and 3-20wt.% based on the whole tablet. The whole tablet is mixed with 0.001-40wt.% of a pharmacodynamically effective component and properly a lubricant, a flavor, a colorant, etc., and pharmaceutically manufactured.;COPYRIGHT: (C)1996,JPO
机译:目的:获得一种含油脂的片剂,该片剂在口腔中迅速崩解,具有光滑而无粗糙感,在口腔中的触感极佳。 ;组成:该片剂既包含第一颗粒,其包含油脂和赋形剂作为必需成分,第二片剂包含第二赋形剂,包含赋形剂作为必需成分,但不含油脂,并且通过压模获得。赋形剂是水溶性糖,例如单糖,寡糖,糖醇等,并且其量基于整个第一颗粒为70-93wt。%,并且基于整个片剂为85-97wt。%。所述油脂在常温下为固体,熔点为30-37℃或与赋形剂混合以显示熔点为30-37℃,并且是植物油脂(例如玉米油),动物油脂。 (例如奶油)和硬脂肪。所含的油脂的量为整个第一颗粒的70-30wt。%和为整个片剂的3-20wt。%。整个片剂与0.001-40wt。%的药效学有效成分以及适当的润滑剂,调味剂,着色剂等混合,并制成药物。COPYRIGHT:(C)1996,JPO

著录项

  • 公开/公告号JP3418274B2

    专利类型

  • 公开/公告日2003-06-16

    原文格式PDF

  • 申请/专利权人 日本化薬株式会社;

    申请/专利号JP19950160139

  • 发明设计人 大朏 和男;小室 主税;大川 文子;

    申请日1995-06-05

  • 分类号A61K9/20;A61K9/26;A61K31/485;A61K47/26;A61K47/44;

  • 国家 JP

  • 入库时间 2022-08-22 00:21:29

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