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Non-aggregated beta forms of prion proteins and antibodies against such proteins
Non-aggregated beta forms of prion proteins and antibodies against such proteins
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机译：非聚集的beta形式的beta病毒蛋白和抗这种蛋白的抗体
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摘要
The present invention relates to a method of making a . b. -form of a prion protein which preferably has more . b. -sheet than . a. -helix structure and is soluble in the absence of a denaturant and/or is non-aggregated and exhibits partial resistance to digestion with proteinase K. The invention also relates to use of the . b. -form in medicine, especially for raising antibodies useful in the treatment and/or diagnosis of prion diseases. The invention also relates to methods of screening for compounds which are capable of inhibiting and/or reversing the conversion of the native . a. -form of a prion protein to a . b. -form, and to uses of identified compounds in medicine.
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