首页> 外国专利> Treatment of diseases associated with peripheral benzodiazepine receptor dysfunction, e.g. peripheral neuropathy, cardiac insufficiency or cancer, using pyridazino(4,5-b)indole-1-acetamide derivatives

Treatment of diseases associated with peripheral benzodiazepine receptor dysfunction, e.g. peripheral neuropathy, cardiac insufficiency or cancer, using pyridazino(4,5-b)indole-1-acetamide derivatives

机译：治疗与周围苯并二氮杂receptor受体功能障碍有关的疾病，例如使用哒嗪（4,5-b）吲哚-1-乙酰胺衍生物的周围神经病，心脏功能不全或癌症

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摘要

Use of 7-halo-1-(2-(piperazin-1-yl)-2-oxoethyl)-4-oxo-3-phenyl-3,5-dihydro-4H -pyridazino (4,5-b) indoles (I) for the treatment or prevention of diseases associated with dysfunction of the peripheral benzodiazepine receptors is new. Use of pyridazino-indole derivatives of formula (I) or their acid addition salts is claimed in the preparation of a medicament for the treatment or prevention of diseases associated with dysfunction of the peripheral benzodiazepine receptors. X = halo; Y = H or one or more of halo, OH, Me and OMe; R1 = H or 1-4C alkyl; and R2 = H, 1-4C alkyl, 3-7C cycloalkyl, (3-7C) cycloalkyl-(1-6C) alkyl, phenyl, pyridinyl or phenyl-(1-4C) alkyl.

机译：使用7-卤代-1-（2-（哌嗪-1-基）-2-氧代乙基）-4-氧代-3-苯基-3,5-二氢-4H-吡啶并（4,5-b）吲哚（ I）用于治疗或预防与外周苯并二氮杂receptor受体功能障碍有关的疾病是新的。要求保护式（I）的哒嗪基-吲哚衍生物或其酸加成盐在制备用于治疗或预防与外周苯并二氮杂receptor受体功能障碍有关的疾病的药物中的用途。 X =卤素; Y ＝ H或卤素，OH，Me和OMe中的一个或多个; R1 = H或1-4C烷基; R2 ＝ H，1-4C烷基，3-7C环烷基，（3-7C）环烷基-（1-6C）烷基，苯基，吡啶基或苯基-（1-4C）烷基。

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公开/公告号FR2811897A1

专利类型
公开/公告日2002-01-25

原文格式PDF
申请/专利权人 SANOFI-SYNTHELABO;
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申请/专利号FR20000009655
发明设计人 BARTSCH LI REGINE;DUBOIS LAURENT;EVANNO YANNICK;FROISSANT JACQUES;GEORGE PASCAL;MARABOUT BENOIT;MARGUET FRANK;SEVRIN MIREILLE;
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申请日2000-07-24
分类号A61K31/496;
国家 FR
入库时间 2022-08-22 00:24:21

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