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Intravenous application form of thalidomide for the therapy of immunological diseases
Intravenous application form of thalidomide for the therapy of immunological diseases
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机译:沙利度胺静脉应用治疗免疫性疾病
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摘要
Stable, aqueous form of (+)-(R)-thalidomide or (-)-(S)-thalidomide contains the enantiomer of thalidomide dissolved in pure form in isotonic glucose solution and has a pH 5.5. An Independent claim is also included for the production of the aqueous thalidomide solution, comprising: (a) adding (+)-(R) or (-)-S-thalidomide to isotonic glucose at pH 4-5; (b) shaking until dissolution is complete; and (c) treating with ultrasound and filtering under aseptic conditions. Use of pure enantiomers of thalidomide allows water-stable solutions that do not give rise to toxicological effects. The enantiomers have higher solubility in water than the racemate. At pH 5.5, hydrolysis of thalidomide does not occur. Solutions are suitable for parenteral administration.
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