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首页> 外国专利> METHOD OF INHIBITING PROTEIN TYROSINE PHOSPHATASE 1B AND/OR T-CELL PROTEIN TYROSINE PHOSPHATASE AND/OR OTHER PTPASES WITH AN ASP RESIDUE AT POSITION 48

METHOD OF INHIBITING PROTEIN TYROSINE PHOSPHATASE 1B AND/OR T-CELL PROTEIN TYROSINE PHOSPHATASE AND/OR OTHER PTPASES WITH AN ASP RESIDUE AT POSITION 48

机译：在位置48处具有ASP残基的蛋白酪氨酸磷酸酶1B和/或T细胞蛋白酪氨酸磷酸酶和/或其他PTP酶的抑制方法

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摘要

The present invention provides a method of inhibiting a member of a family of Protein Tyrosine Phosphatases (PTPases, PTPs) such as PTP1B, TC-PTP, CD45, SHP-1, SHP-2, PTP alpha , PTP epsilon , PTP mu , PTP delta , PTP sigma , PTP zeta , PTP beta , PTPD1, PTPD2, PTPH1, PTP-MEG1, PTP-LAR, and HePTP by exposing said Ptpase member by administration to a host or otherwise to at least one compound with certain structural, physical and spatial characteristics that allow for the interaction of said compound with specific residues of the active site of PTP1B and/or TC-PTP. These compounds are indicated in the management or treatment of a broad range of diseases such as autoimmune diseases, acute and chronic inflammation, osteoporosis, various forms of cancer and malignant diseases, and type I diabetes and type II diabetes, as well as in the isolation of PTPases and in elucidation or further elucidation of their biological function.
机译：本发明提供了抑制蛋白酪氨酸磷酸酶（PTPases，PTP）家族的成员的方法，所述蛋白例如PTP1B，TC-PTP，CD45，SHP-1，SHP-2，PTPα，PTPε，PTPμ，PTP δ，PTP sigma，PTP zeta，PTP beta，PTPD1，PTPD2，PTPH1，PTP-MEG1，PTP-LAR和HePTP，方法是将所述Ptpase成员给药于宿主或以其他方式暴露于至少一种具有某些结构，物理和化学性质的化合物使所述化合物与PTP1B和/或TC-PTP活性位点的特定残基相互作用的空间特征。这些化合物可用于多种疾病的治疗或治疗，例如自身免疫性疾病，急性和慢性炎症，骨质疏松症，各种形式的癌症和恶性疾病，I型糖尿病和II型糖尿病以及分离中。 PTPase的鉴定以及其生物学功能的阐明或进一步阐明。

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