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Three-dimensional structure of bovine rhodopsin

机译：牛视紫红质的三维结构

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摘要

The present invention discloses a three-dimensional structure of bovine rhodopsin. There is provided a G protein-coupled receptor selected from the group consisting of the following (a) and (b):(a) a G protein-coupled receptor having three-dimensional structure I defined by the atomic coordinates as shown in Table 1;(b) a G protein-coupled receptor having three-dimensional structure II defined by derived coordinates from the atomic coordinates as shown in Table 1, wherein the mean residual of the discrepancies between the positions of the α carbon atoms in the amino acid residues of seven helix sites H-I (36-64), H-II (71-100); H-III (107-139), H-IV (151-173), H-V (200-225), H-VI (247-277) and H-VII (286-306) in the amino acid sequence as shown in SEQ ID NO: 1 of the three-dimensional structure I and the positions of the corresponding α cabon atoms in the amino acid residues of the corresponding seven helix sites of the three-dimensional structure II is 1.5 Å or less when an image of the three-dimensional structure I obtained by computer-processing the atomic coordinates of Table 1 and an image of the three-dimensional structure II obtained by computer-processing the derived coordinates are superposed.
机译：本发明公开了牛视紫红质的三维结构。提供了选自以下（a）和（b）的G蛋白偶联受体： （a）一种G蛋白偶联受体，具有由原子坐标定义的三维结构I，如表1所示; （ListItem）（b）具有三维结构II的G蛋白偶联受体，该三维结构II由从原子坐标得出的坐标定义，如表1所示，其中α碳原子的位置之间的差异的平均残差在表1中示出。七个螺旋位点HI（36-64），H-II（71-100）的氨基酸残基;氨基酸序列中的H-III（107-139），H-IV（151-173），HV（200-225），H-VI（247-277）和H-VII（286-306）三维结构I的SEQ ID NO：1和三维结构II的相应七个螺旋位点的氨基酸残基中相应的α碳原子的位置在三个图像时为1.5或更小将通过计算机处理表1的原子坐标获得的三维结构I与通过对导出的坐标进行计算机处理获得的三维结构II的图像叠加。

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