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Vaccine against lyme disease and a challenge model for evaluating vaccine efficacy

机译:针对莱姆病的疫苗和评估疫苗功效的挑战模型

摘要

The invention provides a vaccine for protecting a susceptible mammal from Lyme disease comprising an amount of B. burgdorferi major antigens effective to induce a serum neutralising titer of antibodies againstB. burgdorferi. A process for preparing the vaccine comprising culturing B. burgdorferi bacteria, monitoring the level of one of Osp A or Osp B, inactiving the bacteria when a maximum in the production as one of Osp A or Osp B is obtained, and mixing the inactivated bacteria in a physiologically acceptable carrier is also covered. The invention also includes a process for inducing Lyme disease in a susceptible laboratory mammal comprising injecting virulent B. burgdorferi spirochetes into said mammal in a manner that mimics the transmission of the disease by a tick.
机译:本发明提供了一种用于保护易感哺乳动物免于莱姆病的疫苗,其包含一定量的能有效诱导针对B的抗体的血清中和效价的B.burgdorferi主要抗原。伯格多菲里。一种制备疫苗的方法,该方法包括培养伯氏疏螺旋体细菌,监测Osp A或Osp B之一的水平,当获得作为Osp A或Osp B之一的产量的最大值时使该细菌失活,并混合该失活的细菌。生理上可接受的载体中的糖也包括在内。本发明还包括一种在易感实验室哺乳动物中诱发莱姆病的方法,该方法包括以模仿a传播疾病的方式向该哺乳动物注射强毒的伯氏疏螺旋体螺旋体。

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