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ROLE OF VASCULAR ENDOTHELIAL GROWTH FACTOR-B (VEGF-B) IN DEVELOPING BONES AND USES THEREOF

机译：血管内皮生长因子-B（VEGF-B）在骨骼发育中的作用及其用途

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摘要

This invention relates to the expression of VEGF-B in developing bones. Methods are provided for stimulating angiogenesis of a bone, for stimulating the healing of bone fractures or breaks, for enhancing the acceptance and/or securing of an implant to a bone and for the treatment or alleviation of the inflammation of the epiphysis of a long bone as well as the use of a pharmaceutical composition which comprises a polypeptide having an amino acid sequence of at least 85 % sequence identity with the sequence of SEQ ID NO: 2 or 4, or fragment thereof having the biological activity of VEGF-B to stimulate angiogenesis of a bone.

机译：本发明涉及在发育中的骨骼中VEGF-B的表达。提供了刺激骨的血管生成，刺激骨折或骨折的愈合，增强植入物对骨的接受和/或固定以及治疗或减轻长骨的骨physi发炎的方法。以及包含具有与SEQ ID NO：2或4的序列具有至少85％序列同一性的氨基酸序列的多肽的多肽或其具有VEGF-B刺激生物活性的片段的药物组合物的用途骨骼的血管生成。

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公开/公告号WO0064261A9

专利类型
公开/公告日2002-04-04

原文格式PDF
申请/专利权人 LUDWIG INSTITUTE FOR CANCER RESEARCH;HELSINKI UNIVERSITY LICENSING LTD.;
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申请/专利号WO2000US11096
发明设计人 OLOFSSON BIRGITTA;ERIKSSON ULF;KAIPAINEN ARJA;ALITALO KARI;AASE KARIN;
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申请日2000-04-26
分类号A01N37/18;A01N43/04;A61K31/70;A61K38/00;C07H21/02;C07H21/04;C07K1/00;C07K2/00;C07K4/00;C07K7/00;C07K14/00;C07K16/00;C07K17/00;C12P19/34;C12P21/06;C12P21/08;C12Q1/68;
国家 WO
入库时间 2022-08-22 00:38:40

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