首页>
外国专利>
Gene associating open-angle glaucoma including normal ocular tension glaucoma
Gene associating open-angle glaucoma including normal ocular tension glaucoma
展开▼
机译：包括正常眼压性青光眼的基因相关性开角型青光眼
展开▼
页面导航
摘要
著录项
相似文献
摘要
Polynucleotides having substitution of thymine (T) by cytosine (C) at the -153 position of myocilin gene are identified as glaucoma-associated gene. To detect these polynucleotides, use can be made of primers of SEQ ID NOS:3 to 6 and probes of SEQ ID NOS:7 and 8. Also, kits with the use of the primers of SEQ ID NOS:3 to 6 or the probes of SEQ ID NOS:7 can be provided. Use of these kits makes it possible to detect normal ocular tension glaucoma and open-angle glaucoma at a much higher frequency than in a case with the use of glaucoma-associated genes reported hitherto. Also, these kits are usable in screening glaucoma in patients with a fear of hereditary glaucoma or asymptomatic carriers. Moreover, it becomes possible for the first time to diagnose open-angle glaucoma including normal ocular tension glaucoma prior to the onset.
展开▼
机译：在肌球蛋白基因的-153位具有胸腺嘧啶（T）被胞嘧啶（C）取代的多核苷酸被鉴定为青光眼相关基因。为了检测这些多核苷酸，可以使用SEQ ID NOS：3至6的引物以及SEQ ID NOS：7和8的探针。另外，使用SEQ ID NOS：3至6的引物或试剂盒的试剂盒可以提供SEQ ID NO：7的SEQ ID NO：7。与迄今报道的使用青光眼相关基因的情况相比，使用这些试剂盒可以以更高的频率检测正常的眼压性青光眼和开角型青光眼。同样，这些试剂盒可用于筛选患有遗传性青光眼或无症状携带者的患者的青光眼。此外，在发作之前首次可以诊断包括正常眼压性青光眼的开角型青光眼。
展开▼
