首页> 外国专利> N-ACETYLCYSTEINE COMPOSITIONS AND METHODS FOR THE N-ACETYLCYSTEINE COMPOSITIONS AND METHODS FOR THE TREATMENT AND PREVENTION OF DRUG TOXICITY TREATMENT AND PREVENTION OF DRUG TOXICITY

N-ACETYLCYSTEINE COMPOSITIONS AND METHODS FOR THE N-ACETYLCYSTEINE COMPOSITIONS AND METHODS FOR THE TREATMENT AND PREVENTION OF DRUG TOXICITY TREATMENT AND PREVENTION OF DRUG TOXICITY

机译:N-乙酰半胱氨酸组合物和方法N-乙酰半胱氨酸组合物和方法的治疗和预防药物毒性的治疗和预防药物的毒性

摘要

The invention provides pharmaceutical compositions for the treatment or prevention of the toxic effects of therapeutic agents and methods of treating or preventing such toxicity using a toxicity reducing amount of N- acetylcysteine either alone or in combination with a therapeutically effective amount or, to achieve its therapeutic advantages, an amount larger than what is customarily given as a therapeutically effective amount, of a therapeutic agent. The invention also provides pharmaceutical compositions for the treatment or prevention of the toxic effects of therapeutic agents and methods of treating or preventing such toxicity using a toxicity reducing amount of N- acetylcysteine either alone or in combination with a therapeutically effective amount or, to achieve its therapeutic advantages, an amount larger than what is customarily given as a therapeutically effective amount, of a therapeutic agent whose side effects are made worse by increased oxidative stress or treatment related decreases in subject cysteine/glutathione levels or are otherwise relieved by administration of NAC.
机译:本发明提供了用于治疗或预防治疗剂毒性作用的药物组合物,以及使用减少毒性的量的N-乙酰半胱氨酸单独或与治​​疗有效量组合使用或达到其治疗效果的治疗或预防这种毒性的方法优点是,治疗剂的量大于通常作为治疗有效量给出的量。本发明还提供了用于治疗或预防治疗剂毒性作用的药物组合物,以及使用减少毒性的量的N-乙酰半胱氨酸单独或与治​​疗有效量组合使用或达到其毒性的方法,来治疗或预防这种毒性的方法。具有比常规治疗有效量大的量的治疗优势的治疗优势,其副作用会因氧化应激增加或与治疗相关的半胱氨酸/谷胱甘肽水平降低而恶化,或者通过施用NAC得以缓解。

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