首页> 外国专利> The substituted 4-biarylbutrique or 5-biarylpentanoique acid and its derivatives are used as ` maricielle metalloproteinase inhibitors'.

The substituted 4-biarylbutrique or 5-biarylpentanoique acid and its derivatives are used as ` maricielle metalloproteinase inhibitors'.

机译:取代的4-联芳基丁酸或5-联芳基戊酸及其衍生物用作“马里切尔金属蛋白酶抑制剂”。

摘要

Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The presently claimed compounds have the generalized formula IMAGE in which each T represents a substituent group; x is 0, 1, or 2; D represents IMAGE delta is 0 or 1; U' represents O, S, or N, with the proviso that when U' is N, then delta =0, and when U' is O or S, then delta =1; R14 is any of a variety of substituent groups; and G represents M, IMAGE in which M represents -CO2H, -CON(R11)2, or -CO2R12, R11 represents H or an alkyl group, R12 represents an alkyl group, and R13 represents any of the side chains of the 19 noncyclic naturally occurring amino acids; and pharmaceutically acceptable salts thereof.
机译:基质金属蛋白酶的抑制剂,包含它们的药物组合物以及使用它们治疗多种生理状况的方法。本发明要求保护的化合物具有通式,其中每个T代表取代基; x是0、1或2; D表示增量为0或1; U'表示O,S或N,条件是当U'为N时,delta = 0;当U'为O或S时,delta = 1; R14是各种取代基中的任何一个; G表示M,,其中M表示-CO 2 H,-CON(R 11)2或-CO 2 R 12,R 11表示H或烷基,R 12表示烷基,R 13表示烷基的任何侧链。 19种非环状天然氨基酸;及其药学上可接受的盐。

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