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首页> 外国专利> New Derivatives of hexa -, penta - and Tetra peptides as inhibitors of hepatitis C.Understanding their racematos Optical isomers, Diastereomers and and Method for preparing the same

New Derivatives of hexa -, penta - and Tetra peptides as inhibitors of hepatitis C.Understanding their racematos Optical isomers, Diastereomers and and Method for preparing the same

机译：六，五和四肽的新衍生物作为丙型肝炎的抑制剂了解它们的消旋体光学异构体，非对映异构体及其制备方法

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A formula compound (I),including racemates, diastereoisomers and optical isomers: EMI FILE = "99050711_1" ID = "1" IMF = JPEG where a is 0 or 1; b is 0 or 1; Y is H or C1-C6 alkyl .;B is H, an acyl derivative of formula R7-C (O) -or a sulfonyl of formula R7-SO2 where R7 is (i) C1-C10 alkyl, optionally substituted with carboxyl, C1-C6 alkanoyloxy. or C1-C6 alkoxy; (ii) C3-C7 cycloalkyl, optionally substituted with carboxyl, (C1-C6 alkoxy) carbonyl or phenylmethoxycarbonyl; (iii) C6 0 C10 aryl 0 C7-C16 aralkyl optionally substituted with C1-C6 alkyl; hydroxy or amino optionally substituted with C1-C6 alkyl; or (iv) Het optionally substituted with C1-C6 alkyl, hydroxy, amino optionally substituted with C1-C6 alkyl or amido optionally substituted with C1-C6 alkyl; R6, if present, is C1-C6 alkyl substituted with carboxyl; R5,R2 is c122 to R20, nh-r20, or 20th or s-r20, where 20 and R20, 20 or (o) c4-c10 in 20 or R20 It's a selective monkeyDi-o tri replace with R21, O R20, arilo C6 or C10, or aralquilo C7Di-o tri replaced with R21, or R20 is het or het - (C1-C6 tar) optional monkey-di-o tri-sustituido con R21en donde cada R21 es independientemente alquilo C1-C6 alcoxi C1-C6 amino opcionalmente mono-o di-sustituido con alquilo C1-C6 sulfonilo NO2 OH SH halo haloalquilo amido opcionalmente mono-sustituido con alquilo C1-C6 Arilo C6 or C10, aralquilo c7-c16 or het, wherein arilo, aralquilo or het can be replaced by R22; R22 is C1-C6 tar; Alcoy C1-C6; optional monoamine or di - is replaced by C1-C6 tar; sulfuric acid; NO2; Oh; SH; halo; halogen; carboxyl
机译：式（I）的化合物，包括外消旋体，非对映异构体和旋光异构体：其中a为0或1; b为0或1; Y是H或C1-C6烷基。; B是H，式R7-C（O）的酰基衍生物或式R7-SO2的磺酰基，其中R7是（i）任选被羧基取代的C1-C10烷基， C 1 -C 6烷酰氧基。或C1-C6烷氧基; （ii）任选地被羧基，（C 1 -C 6烷氧基）羰基或苯基甲氧基羰基取代的C 3 -C 7环烷基; （iii）任选地被C 1 -C 6烷基取代的C 6 0 C 10芳基0 C 7 -C 16芳烷基;任选被C 1 -C 6烷基取代的羟基或氨基; （iv）任选被C1-C6烷基取代的Het，羟基，任选被C1-C6烷基取代的氨基或任选被C1-C6烷基取代的酰胺基;或如果存在的话，R6是被羧基取代的C1-C6烷基; R5，R2是c122到R20，nh-r20或20th或s-r20，其中20和R20、20或（o）c4-c10在20或R20中。 arilo C6或C10，或aralquilo C7Di-o tri被R21取代，或R20是het或het-（C1-C6焦油）可选的猴子-di-o tri-sustituido con R21en donde cada R21 es独立性alquilo C1-C6 alcoxi C1 -C6氨基单-o-二-ustusionido con alquilo C1-C6磺酰基NO2 OH SH卤代卤代alquilo酰胺基Opcionalmente单--sustituido con alquilo C1-C6 Arilo C6或C10，aralquilo c7-c16或het，其中arilo，aralquilo或het可以被R22取代; R22为C1-C6焦油;铝C1-C6;任选的单胺或二-被C1-C6焦油取代;硫酸; NO2;哦; SH;光环;卤素;羧基

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