首页> 外国专利> Process for identifying translated expression proteins from a nucleotide sequence, purified recombinant protein, nucleotide sequence, screening processes for identifying expression clones in a library, for screening a library of nucleotide sequences, for identifying antigenic gene sequences for a sample of nucleotide sequences and to identify a therapeutic antigenic gene sequence, recombinant vector, host cell, amino acid sequence, isolated and purified polypeptide, antibody, and process for treating an infection.

Process for identifying translated expression proteins from a nucleotide sequence, purified recombinant protein, nucleotide sequence, screening processes for identifying expression clones in a library, for screening a library of nucleotide sequences, for identifying antigenic gene sequences for a sample of nucleotide sequences and to identify a therapeutic antigenic gene sequence, recombinant vector, host cell, amino acid sequence, isolated and purified polypeptide, antibody, and process for treating an infection.

机译：从核苷酸序列，纯化的重组蛋白，核苷酸序列鉴定翻译的表达蛋白的方法，在文库中鉴定表达克隆，筛选核苷酸序列的文库，鉴定核苷酸序列样品的抗原基因序列并鉴定的筛选方法治疗性抗原基因序列，重组载体，宿主细胞，氨基酸序列，分离和纯化的多肽，抗体以及治疗感染的方法。

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摘要

"PROCESS TO IDENTIFY protein expression TRANSLATION OF A nucleotide sequence, protein purified recombinant, nucleotide sequence, SCREENING PROCESS TO IDENTIFY EXPRESSION OF CLONES IN A LIBRARY FOR SCREENING OF A nucleotide sequences LIBRARY TO IDENTIFY gene sequences antigenic OF A SAMPLE OF NUCLEOTIDE SEQUENCES AND TO IDENTIFY A THERAPEUTIC ANTIGEN GENE SEQUENCE, RECOMBINANT VECTOR, HOST CELL, Amino Acid Sequence, ISOLATED AND PURPOSE, INFECTED AND PROPECTED PURPOSE. The present invention relates to methods for identifying potential vaccine antigen gene sequences. Also included are gene sequences and polypeptides encoded by the gene sequences, as well as the use of these sequences to induce a protective immune response in animals. Particularly, the invention relates to the identification of potential Mycoplasma antigen gene sequences, preferably Mycoplasma hyopneumoniae. In one aspect of the present invention there is provided a method for identifying expression proteins translated from a nucleotide sequence into an expression vector, said method comprising using a marker co-expressed with a protein translated from a nucleotide sequence. In another aspect of the present invention there is provided a method for identifying a therapeutic antigenic gene sequence encoding a disease therapeutic antigenic protein from a nucleotide sequence sample. Preferably, the label is a polyHis tag.

机译：“鉴定核苷酸序列的蛋白质表达翻译的过程，蛋白质纯化的重组体，核苷酸序列，鉴定图书馆中克隆表达的筛选过程，鉴定核苷酸序列的文库以鉴定对核苷酸序列样品有抗原性的基因序列并鉴定治疗性抗原基因序列，重组载体，宿主细胞，氨基酸序列，分离和目的，感染和目的目的本发明涉及鉴定潜在疫苗抗原基因序列的方法，还包括基因序列和由该基因编码的多肽。序列，以及这些序列在动物中诱导保护性免疫应答的用途，特别是，本发明涉及潜在的支原体抗原基因序列的鉴定，优选地是猪肺炎支原体。用于鉴定从fr翻译的表达蛋白从核苷酸序列到表达载体中，所述方法包括使用与从核苷酸序列翻译的蛋白质共表达的标志物。在本发明的另一方面，提供了一种从核苷酸序列样品中鉴定编码疾病治疗性抗原蛋白的治疗性抗原基因序列的方法。优选地，标签是polyHis标签。

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公开/公告号BR9915066A

专利类型
公开/公告日2002-01-15

原文格式PDF
申请/专利权人 COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION;
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申请/专利号BR19999915066
发明设计人 ROBERT JOHN MOORE;TIMOTHY JAMES DORAN;
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申请日1999-11-19
分类号C07K1/13;C07K19/00;C12N15/62;A61K38/16;A61K31/70;A61K39/02;
国家 BR
入库时间 2022-08-22 00:45:54

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