首页> 外国专利> Process for reducing atherosclerotic plaques in a mammal, method for treating atherosclerosis in a mammal, composition, methods for providing biologically active lipid hydrolyzing protein or polypeptide or mixture thereof, for cells of a mammal having biologically hydrolyzing lipid protein or polypeptide active, to provide biologically active lysosomal acid lipase to cells of a mammal having biologically active lysosomal acid lipase deficiency, to provide biologically active lysosomal acid lipase to cells of a mammal with atherosclerosis, to treat wolman's disease in a mammal , for treatment of cholesterol ester storage disease in a mammal, and for treatment of atherosclerosis in a mammal

Process for reducing atherosclerotic plaques in a mammal, method for treating atherosclerosis in a mammal, composition, methods for providing biologically active lipid hydrolyzing protein or polypeptide or mixture thereof, for cells of a mammal having biologically hydrolyzing lipid protein or polypeptide active, to provide biologically active lysosomal acid lipase to cells of a mammal having biologically active lysosomal acid lipase deficiency, to provide biologically active lysosomal acid lipase to cells of a mammal with atherosclerosis, to treat wolman's disease in a mammal , for treatment of cholesterol ester storage disease in a mammal, and for treatment of atherosclerosis in a mammal

机译：减少哺乳动物动脉粥样硬化斑块的方法，治疗哺乳动物动脉粥样硬化的方法，组合物，提供具有生物水解脂质蛋白或多肽活性的哺乳动物细胞的生物学活性脂质水解蛋白或多肽或其混合物的方法，以提供生物活性活性溶酶体酸性脂肪酶对具有生物活性溶酶体酸性脂肪酶缺乏症的哺乳动物的细胞，向具有动脉粥样硬化的哺乳动物的细胞提供生物活性溶酶体酸性脂肪酶，以治疗哺乳动物的狼疮病，用于治疗哺乳动物的胆固醇酯贮积病，并用于治疗哺乳动物的动脉粥样硬化

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摘要

"PROCESS TO REDUCE ATHEROSCLEROTIC PLATES IN A MAMMALIAN, METHOD FOR TREATING AEROSCLEROSIS IN A MAMMALIAN, COMPOSITION, METHODS FOR PROTECTING A HYDROLYTIC HYDROIDIC MIPHYLINGOUS HYDROPHYLATIC HYDROPHYOTHERAPY BIOLOGICALLY ACTIVE, TO PROVIDE LYSOSOMAL ACID LIPASE BIOLOGICALLY ACTIVE FOR CELLS OF A MAMMALIAN HAVING DEFICIENCY OF LYSOSOMAL ACID LIPASE BIOLOGICALLY ACTIVE, TO PROVIDE LYSOSOMAL ACID LIPASE OF MAMMUSALLY ACTIVE MOLIONICALLY ACTIVE MOLION MAMIFERO, FOR TREATMENT OF COLESTERIL ESTER STORAGE DISEASE IN A MAMIFERO, AND FOR TREATMENT OF AEROSCLEROSIS IN A MAMIFERO ". The present invention comprises a method to decrease and / or eliminate atherosclerotic plaques in mammals, through direct and indirect treatment of these plaques, in situ, using suitable substances, which are capable of removing lipid, mainly through hydrolysis, for a catalytic or stoichiometric process, in which the substance targets receptors inside and / or over the cell, which leads to uptake into the lysosome. Such substances used to decrease and / or eliminate atherosclerotic plaques are generally comprised of lipid hydrolyzing proteins and / or polypeptides.

机译：“减少哺乳动物动脉粥样硬化板的过程，一种在哺乳动物中治疗气固性的方法，组成，用于保护羟基水解的羟基纤维素的生物活性，对蛋白质水解的纤维素酶呈酸性，呈酸性，呈酸性，呈酸性，呈酸性，呈酸性，呈酸性，呈酸性，呈酸性，呈酸性。 “具有生物活性，以提供哺乳动物活性的分子活性的MOLION MAMIFERO的溶酶体脂酶，用于治疗MAMIFERO中的胆固醇酯类疾病，以及用于治疗MAMIFERO中的气固性硬化”。本发明包括减少和/或消除哺乳动物动脉粥样硬化斑块的方法，该方法是使用合适的物质原位直接和间接地原位处理这些斑块，所述物质能够通过催化或化学计量过程主要通过水解来去除脂质。，其中该物质靶向细胞内部和/或细胞上方的受体，导致被溶酶体吸收。用于减少和/或消除动脉粥样硬化斑块的此类物质通常由脂质水解蛋白和/或多肽组成。

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公开/公告号BR0108077A

专利类型
公开/公告日2002-10-22

原文格式PDF
申请/专利权人 CHILDRENS HOSPITAL RESEARCH FOUNDATION;
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申请/专利号BR20010108077
发明设计人 GREGORY A. GRABOWSKI;HONG DU;
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申请日2001-02-02
分类号A61K38/46;A61K48/00;A61P9/10;A61P3/06;
国家 BR
入库时间 2022-08-22 00:46:06

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