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Compounds, pharmaceutical composition, use of a compound, methods to treat disorders and to reduce craving in humans and weight gain after smoking cessation in humans and process for preparing compounds
Compounds, pharmaceutical composition, use of a compound, methods to treat disorders and to reduce craving in humans and weight gain after smoking cessation in humans and process for preparing compounds
"COMPOUNDS, PHARMACEUTICAL COMPOSITION, USE OF A COMPOUND, METHODS TO TREAT DISORDERS AND TO REDUCE THE ASTH TO SMOKE IN HUMAN BEINGS AND WEIGHT GAIN AFTER THE CESSATION OF SMOKING IN HUMAN BEINGS AND THE PROCESS TO PREPARE COMPOUNDS". The compounds of formula (I) including their pharmaceutically acceptable ones, wherein A is S or O; R ~ 1 ~ is H, halo, a C ~ 1-3 ~ alkyl group or a C ~ 1-3 ~ alkyl group; R ~ 2 ~ is H or fluorine; and R ~ 3 ~ is methyl, ethyl or isopropyl, are useful in the treatment of depression, anxiety, psychosis (eg schizophrenia), tardive dyskinesia, obesity, drug addiction, drug abuse, cognitive disorders, Alzheimer's disease, cerebral ischemia , obsessive-compulsive behavior, panic attacks, social phobias, eating disorders such as bulimia, anorexia, light eating and drinking, non-insulin dependent diabetes mellitus, hyperglycemia, hyperlipidemia, stress, and in the treatment and / or prophylaxis of seizures, neurological disorders such as epilepsy and / or conditions in which there was neurological damage, such as stroke, brain trauma, cerebral ischemia, injuries and bleeding in the head.
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机译：“化合物，药物成分，化合物的使用，在人类戒烟后以及在制备化合物的过程中治疗疾病和减少烟熏的方法和减轻体重增加的方法”。式（I）的化合物，包括其药学上可接受的化合物，其中A为S或O; R〜1〜是H，卤素，C〜1-3〜烷基或C〜1-3〜烷基; R〜2〜是H或氟; R 3〜为甲基，乙基或异丙基，可用于治疗抑郁症，焦虑症，精神病（例如精神分裂症），迟发性运动障碍，肥胖症，药物成瘾，药物滥用，认知障碍，阿尔茨海默氏病，脑缺血，强迫症强迫行为，惊恐发作，社交恐惧症，进食障碍，例如贪食症，厌食症，进食和饮酒，非胰岛素依赖型糖尿病，高血糖，高脂血症，压力，以及在治疗和/或预防癫痫发作中，神经系统疾病如癫痫病和/或出现神经系统损害的情况，例如中风，脑外伤，脑缺血，头部受伤和出血。
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